69itis Share definition Flag The act of uncontrollably laughing due to the number 69 Teacher: "Okay class, x=69" Ally: "HAHAHAHAHAHAHAHAHAHAHA" Anna: "Looks like you got 69itis" 69itis by Brooke Sexton February 27, 2009 0 0 Get merch Get the 69itis mug. Buy Now — $32.95 See more merch