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Tangentacide 

When a person goes of on a tangent and completely destroys the conversation or atmosphere.
You are having a nice evening down the pub and you are explaining to the assembled crowd of friends something exciting or retelling an old story and you wander off on a massive tangent which at the end has either offended, confused, alienated or stunned your friends into a silence as they contemplate your mental health. Or one of your friends does that.

That is Tangentacide. Often followed by people sneaking away from the table, needing the toilet or finding out their friends are in dire trouble and they must leave.
Tangentacide by matthaisz October 10, 2010

Tangentalized 

This has got to be the most tangentalized topic i've ever been to.
Tangentalized by Zyzic September 10, 2005

tangentialize 

(verb)

1. To go off on a tangent mid-conversation.

2. To pirate a conversation away from its natural course.
Let's stop tangentializing so we can figure out what we're doing tonight.

When I'm talking with her, Kristen tangentializes so often that I can't ever remember what we were originally talking about.
tangentialize by Pabloney April 25, 2011