Jerkslut Share definition Flag A Male who'm treats the ladies he's seeing like shit, and moves from woman to woman gathering STDs. OMGWTF... Nick has sooo many STDs, the guy is such a Jerkslut. Jerkslut by Peter Piper August 31, 2005 0 0 Get merch Get the Jerkslut mug. Buy Now — $32.95 See more merch