Drydenitis Share definition Flag Engaging in the act of masturbating with dish soap causing your nut sack to dry out, turn red & peel. "Damn it Mike, stop using dish soap while wacking off..... Now you have Drydenitis." Drydenitis by Coonetta November 2, 2008 0 0 Get merch Get the Drydenitis mug. Buy Now — $32.95 See more merch