Cheer up, bitch! Share definition Flag A prescription given to "hysterical" women before antidepressants and Xanax were invented. My wife just had a baby and is suffering from post-partum depression, so the doctor prescribed her to "cheer up, bitch!". Cheer up, bitch! by Betchaann June 19, 2020 0 0 Get merch Get the Cheer up, bitch! mug. Buy Now — $32.95 See more merch