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a)The amount of feet in one mile
b) a gang based in Denver, Colorado being notoriously run by "The Italian Stallion"
Yo bitch, you heard of that hard core gang?
Ya bitch, its called 5280
5280 by Cracker Bitch November 8, 2004
Related Words
A cycling team based out of Denver, Colorado. They are a band of homosexuals and one mental retard. They ride crappy ass javelin bikes and can't do good at anything at nationals besides the time trial.
Cyclist #1: Man, everyone on 5280 is such a dumb cocky ass ridding bitch.
Cyclist #2: Alex isnt that bad, but Walker shows people his nuts
Cyclist #1: Yeah, Walker's a dumb sack of shit
5280 by ishkahar November 7, 2008

5280 feet 

Wow a mile is 5280 feet... nerd
5280 feet by Faint 750 December 25, 2020

Speedbird 5280 

The act of joining the mile high club onboard a British Airways flight
A: "How was your flight to London?"
B: "Awesome. I got a Speedbird 5280!"