gufiao Share definition Flag Gufiao means "cool" in Puerto Rican Spanish. It can also mean "awesome," "coolies," etc. Anything pertaining to something that is neat. "El show fue gufiao!" - "The show was awesome!" gufiao by Deglynx October 15, 2006 0 0 Get merch Get the gufiao mug. Buy Now — $32.95 See more merch