Thugacaine Share definition Flag A sensation of thug that only comes as if your using drugs; reaching the peak of your thug life. guy 1: yo mr brownstone you look thug today mr brownstone: Yeah i'm on my thugacaine splif Thugacaine by pitsalmighty October 10, 2011 0 0 Get merch Get the Thugacaine mug. Buy Now — $32.95 See more merch