methamfagamine Share definition Flag The tendency for previously straight males to start playing for the other team after picking up a meth habit. "I didn't know (tweeker) is into dudes now!" "Yeah, you gotta watch out for that methamfagamine." methamfagamine by Kaylee123 June 14, 2008 0 0 Get merch Get the methamfagamine mug. Buy Now — $32.95 See more merch