A phrase said when somebody/something is acting wild, out of hand or irregular. Mostly said to/about someone after being fuelled by (but certainly not limited to) drugs, anger, bullshit/lies, etc.
“Yo, Derek was so angry after losing the fight. He’s off the crumb right now”
“Derek is high as shit right now, he’s off the crumb”
bro 1: “DEREK YOURE DRIVING SO FAST!”
bro 2: “YEAH DEREK’S OFF THE CRUMB”