1 definition by Woody Woodsfurd
A disease commonly found in professional quarterbacks. When a quarterback is infected he can throw 2-4 interceptions in a game. In most instances, the infection will last only a single game, however it can last for a quarterbacks entire career.
Matt: Hey did you see the Bears quarterback last night?
Ryan: Yeah he had a bad case of Madden brain.
Ryan: Yeah he had a bad case of Madden brain.
by Woody Woodsfurd January 11, 2021