When one becomes not unlike a certain IRC lurker:
Gay, obbsessed with Anime, furries and computers in general.
Symptoms of "Smackification" include random outbursts of incoherency, peaked interest in the same sex, and/heavy metal music.
Can be used in both a derrogatory and complimentary way.
"You are SO smackified today" <when referring to someones random outbursts)
"Have you undergone some rapid smackification lately?" <when a previously unknown metalhead is revealed>