1 definition by Joe Blaze
To be fucked up on whatever your drug of choice is. It is beyond just tipsy or lightheaded, it's full on faded/twisted/tweaked/trippin/high/etc.
Damn, Rick James was on one back in the 80's.
That bum jackin off in the corner must be on one, damn tweak.
That bum jackin off in the corner must be on one, damn tweak.
by Joe Blaze January 25, 2008