Duff

Duff is an acronym meaning Dumb Ugly Fat Friend or Designated Ugly Fat Friend.

Generally a cockblocker and a bitch, have a desperate friend take her down.

Friend 1: Dude I want to hook up with that girl, but her duff is in my way.

Friend 2: It may be Amber but i'll take the duff down.

by Jap Anus Relations July 30, 2009