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Definitions by Iron John Kidd

expression of disbelief, anger, exasperation, or humor; expression used to indicate a rather poignant situation; often used in conjunction with a raised, open hand
Drunken Bill says to drunken Rich, "Bro, your girlfriend is fatter than shit."

Drunken Chuck, watching the whole situation from the side, exclaims with a raised hand, "GRIME!"
Grime by Iron John Kidd December 16, 2004