1 definition by History Channel

An acute, highly infectious, often fatal disease caused by a poxvirus and characterized by high fever and aches with subsequent widespread eruption of pimples that blister, produce pus, and form pockmarks. Also called variola.

After 9/11, there was concerns terrorists might use smallpox in an attack.

Supposedly the US holds enough vaccine for it's entire population in case there were ever an outbreak.
Don't get smallpox, or else you are screwed.
by History Channel November 27, 2005
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