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Definitions by Chandler Bing's forehead

Brian syndrome 

Being the person in your squad that is constantly single and has to watch all of their friends fall in love. Common side effects include: kissing papers constantly, cool scarves, peanut butter and jelly sandwiches, and losing of eyebrows. COOL RAY BANS
CLAIRE: oh hey, why aren't you hanging out with your usual friends
You: I have crippling Brian syndrome