Top definition
Being the person in your squad that is constantly single and has to watch all of their friends fall in love. Common side effects include: kissing papers constantly, cool scarves, peanut butter and jelly sandwiches, and losing of eyebrows. COOL RAY BANS
CLAIRE: oh hey, why aren't you hanging out with your usual friends
You: I have crippling Brian syndrome
by Chandler Bing's forehead April 19, 2017
Happy St. Patties Day!