1. To lose one’s mind completely, generally with a violent or surprising effect on those around the individual who is going crazy.
2. To take on the attributes of a Hard Ass Mafucka.
El-P* is gon' bang these suckas like on Hard Ass MaFucka. He's goin' HAM, son!:
"I am Sam, I am known to go HAM, the full retard!"
*(the legendary MC / Producer and Drunken Master)