Ziphead 

In the sci-fi book 'A deepness in the sky' by Vernor Vinge, zipheads are 'focused' persons in that they are utterly loyal and willing slaves whose attention can be focused on any facet of their personality to serve the needs of the controlling person. For example, a brilliant person can be turned into an utter genius. The ziphead will no longer have any free will and do not care, the slightest bit, about the things unrelated to what they were focussed into. They will become highly agitated and violent if not allowed to do what they were focussed to do.

'Focus' is a tailored infection of the ziphead's brain by a special virus which can be controlled using MRI.

Characters in the novel who were focused (or who were zipheadized)
Ali Lin: A good park designer who became a park designing genius.
Trixia Bonsol: A linguist who became a genius at it.

Ziphead by sherkaner underhill March 18, 2008

Ziphead 

One who is addicted to Zip, a popular mind altering drug that when taken in large doses causes a chain reaction that sends one's life straight down the tubes.

"Hilldale. Nothing but a breeding ground for Tranks, Lobos and Zipheads."
-Black Cop

Ziphead by Martin McFlie July 22, 2006

Zedheads 

Zedheads.com is a web community of defectives and geniuses, old and bitter, young and naive; meaty, yet chock full of vegetables, they make a stew that's an acquired taste.

http://zedheads.com/comments.aspx?LinkID=7208

Zedheads by DanceMotherf*ckerDance November 2, 2008

Ziphead 

the meaning its when someone does something dumb

Can fish swim ?
No
You ziphead

Ziphead by 4JKB December 17, 2018

zedhead 

An Australian, typically middle-aged-to-old, who rejects all things American and insists on doing things the way they were done during times when the country’s only major foreign influence was Britain. Examples include insisting on pronouncing the name of the letter Z ‘zed’ instead of ‘zee’ and never celebrating Halloween.

I’m going to the Halloween party, Dad! Don’t be a zedhead!

zedhead by PonyTrainBoi April 5, 2021