Top Definition
Abbreviation for 'You Sick Fuck'.
I can't believe you dipped your balls in the pizza dough, ysf.
by Duane April 24, 2005
You Stupid F***.
Michael, YSF, you miss the whole point.
by Rudy1957 January 28, 2009
Your So Fucking Sexy
Damn girl YSFS
by SmexxySnarf June 29, 2011
short for "You're So Funny"
lol that was a good joke! YSF!
by MAN (My anonymous name) February 19, 2011

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