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1.
Another name for the street drug ecstasy. An ecstasy pill.
"Can I get some xo's for 10 a pill?"

"Hell naw."
by I know the lingo November 13, 2007
 
2.
Xos
The title given to a select few males in each generation. Derived from Xosae, which is the formal name given to cursed children to ensure they remain safe from evil.
The boy has been dubbed Xos.
by crique July 11, 2008