Literally: "to have been brought down to wuss level". Something or somebody good and authentic that has been dumbed down, gentrified and made palatable to metrosexuals, and even girls.
A double decaf soy latte is a wussified cup of Joe.
Wii is a wussified PlayStation.
iPhone is a wussified cellphone.
iPod is a wussified mp3 player.
"Look! I've tied a very pretty pink ribbon around that awful dog of yours."
"Oh god, no! You've wussfied Conan!"