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1.
A phrase used by ignorant people either to deflect a question that they were not prepared to answer, or because they are in an uncomfortable situation that is beyond their grasp.
-Sitting in an interview-

"So, what kind of work have you done?"

"Who me?"
by DLSmith April 20, 2006
 
2.
A person who responds when you call out to them on the street as "Who, me?".
Cop: Hey you, we need to talk.
Citizen: Who, me?
by John February 04, 2004