Means the same thing as:
What is WRONG with you?
Are you STUPID?
Are you HIGH?

Basically used if you don't understand how someone could ask a really stupid question.
Or if they will not leave you alone.
Girl 1: The sun goes around the Earth, right?

Girl 2: OhmiGAWD what are you DOING with your life?

Boy: keeps taking girl's phone while she's working

Girl: "Fucking knock it off!"

Boy: puts phone back on table, waits a few seconds & looks away, then takes phone again

Girl: Wrestles with boy for her phone "Oh my effing god, what are you DOING with your life?!"
by JakartaTaco June 17, 2011
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The only other thing to have is a woman letting you bang her. What else could he theoretically have?
Hym "What else do you have in your life? What else is there to have? Friends? Check. Family? Check. I don't like the effect they have on my life but they're there. Money? When I actually get paid for the work I do, yes. Accomplishments? I'm objectively one of the greatest writers in history of humanity. So, yes again. Hobbies? Yup. Genius intellect? Yessir. Magnificent penis? Obviously. Status? Doesn't exist but if it DID I would have more of it than everyone. Disciples? More than Jesus. Energy? The maximum amount of that. The real thick kind. It's pungent. The only things I DON'T have are women and Adderall and I only don't have them because YOU don't take instructions very well! I don't know if that's some kind of deformity or a malformed lobe or what but- Oh! An unyielding, ceaseless hatred for everything. I have that too! No 6 pack though... But that's fine... And you all definitely can be full of yourselves. I mean, a lot of you seem to think you have 'the right values' and that promotion of these values is commensurate with virtue and that your ability to promulgate these values and the money people through at you is evidentiary of some sort of cosmic deservedness and that you have some sort of responsibility to prevent people from promoting 'the wrong values' and in doing so you are controlling the minds of your viewers. That's your role in society to you. Controlling the people who watch your content by feeding them 'Good, healthy, positive thoughts.' "
by Hym Iam November 7, 2023
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