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Means the same thing as:
What is WRONG with you?
Are you STUPID?
Are you HIGH?

Basically used if you don't understand how someone could ask a really stupid question.
Or if they will not leave you alone.
Girl 1: The sun goes around the Earth, right?

Girl 2: OhmiGAWD what are you DOING with your life?

Boy: keeps taking girl's phone while she's working

Girl: "Fucking knock it off!"

Boy: puts phone back on table, waits a few seconds & looks away, then takes phone again

Girl: Wrestles with boy for her phone "Oh my effing god, what are you DOING with your life?!"
by JakartaTaco June 17, 2011