What is WRONG with you?
Are you STUPID?
Are you HIGH?
Basically used if you don't understand how someone could ask a really stupid question.
Or if they will not leave you alone.
Girl 2: OhmiGAWD what are you DOING with your life?
Boy: keeps taking girl's phone while she's working
Girl: "Fucking knock it off!"
Boy: puts phone back on table, waits a few seconds & looks away, then takes phone again
Girl: Wrestles with boy for her phone "Oh my effing god, what are you DOING with your life?!"