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Meaning: What the fucks up?
Started from the Truth commercials that are against the tobacco companies.
Tobacco companies compared the addictivness of nicotine to jogging and m&m's. Whadafxup?
whadafxup by Alk3 Ownz U July 31, 2006
Related Words
1) Stands for what the fuck is up?

2) A commercial trying to inform people about "Big Tobacco's crazy ways and addictive products"
whudafxup with that!?

WOW, I love that whudafxup commercial!
whudafxup by bockz April 16, 2007

whuddafxup? 

Slang for "What The Fuck Is Up?"
But, it sounds cooler.
lolz.
Gina kissing a girl.
Mariah walks in.
Mariah- "whuddafxup? WHUDDAFXUP?!?!?!?!"
Gina- "I'm so sorry............."
whuddafxup? by MariahGina March 25, 2007

Whaddafuh 

It's the G (for ghetto or gangster) version of saying the phrase "What the fuck"
Bristol Palin is on Dancing With the Stars?! Whaddafuh?!
Whaddafuh by lovelaughlaurie November 11, 2010

Waddafuxup

Internet slang for "What the fuck's up"(1). Often used to bypass moderate filters.

May have "suffixes"(2) added to the end to produce an extended form of the word.
1. "Waddafuxup man?"

2. "Can anyone help me? My game crashes as soon as I turn it on and it just came out of the box!"
"Sorry man, I don't know waddafuxupwit your game."
Waddafuxup by smurfettte February 18, 2009
slang that is used to mean "what the fuck is up?"
is also an anti-tobacco ad capaignhttp://www.whudafxup.com/
shelly.. whudafxup w/that?
whudafxup by dfhdfh September 3, 2008