To shoot or (sometimes stab)a person several times, usually in an attempt to murder them. Called "wet up" because there is enough blood to soak their clothes, leaving them "wet".
example of wet up:

" Set me up, wet me up, niggas stuck me up
Heard the guns bust but you tricks never shut me up" -2Pac
by MeAgain October 15, 2006
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To be shot up stabbed resulting in death.
Man Marcus was stuntin on some bangsta last night and got wet up.
by Young Ceize August 17, 2005
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to be soaked and drenched in your own blood due to gunshots or stab wounds
i heard someone got "wet up" at the ghetto club uptown last night.
by JakeJohn August 10, 2012
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To take shots or drink any alcoholic beverage, mainly vodka/liquor to the point you are atleast tipsy.
Yo, its thirsty thursday and we got drinks on deck. That means its time to get Wet Up! Holla Atcha Gwalla
by TeddiGraham March 3, 2010
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To verbally outline your excited emotion whilst hang gliding!
Hahaha did you hear Wilson yelp 'Wet up' as he landed?!?!
by Wilson_fly August 24, 2010
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1. A drive by shooting where multiple shots are fired
2. To arouse a group of girls solely based on your appearance and suave
1. In the studio...

21 Savage: Wet yo mama house, wet yo grandma house, keep shooting till somebody die

Metro Boomin: Yo! That was bars bro! Did you really Wet up the block?

21 Savage: Hell ya! I'm a real street nigga, bitch, i am not one of these niggas bangin' on wax

2. Rachael: Did you see Joey's haircut?

Monica: Yes I did! He's such a beautiful man

Rachael: I know! He had all those girls going crazy, literally trembling to there knees

Monica: Yup! He really Wet up the block!
by ACU_$tyle June 8, 2017
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