Refers to a semi-serious malady whereby an impatient/cantankerous person habitually "whimpers 'n' growls" using long drawn-out wordless/meaningless noises that, if written out phonetically, would consume a whole lotta letters other than consonants, such as "Aaaaaaaaaarrgghhhuuuuuuuuuhhhhh...!" or, "Eeeeeeeeeennnggguuuuuuuuuhhh...!"
I never take my spoiled-rotten teenage cousin along on family shopping-trips anymore... the lengthy wait-times between stores, our unwillingness to purchase the unnecessary/overly-expensive items he desires, our inability to go around to all the places he wants to visit, and the late hour that we usually get home all conspire to give him a major case of irritable vowel syndrome, and this constant fretting takes all the cheerfulness out of the trip for everyone else.
by QuacksO September 24, 2017
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When playing scrabble and you keep getting vowels, turn after turn, even when you exchange tiles.
I cannot believe it, this is the third turn I am only getting vowels in this Scrabble round, I must have Irritable vowel syndrome (I.V.S.)!
by Farshad Tami September 13, 2019
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1. To describe someone who is doing tricks with the smoke from any nicotine device, usually a hookah
2. To describe someone who is getting really high from any nicotine device

Derived from a scene from the original Alice in Wonderland where the blue caterpillar is seen creating vowels from the smoke from his hookah
Dude that smoke ring was sick! You for real smoking vowels over there.
by gulia4549 December 28, 2022
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