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To smack down, to destroy, to annihilate. Up in your face, in your grill.

A group of online gamers that play on all gaming systems.
Player 1: Have you guys played against anyone who has UPnU in their tag?

Player 2: No.

Player 1: Man they kicked our ass last night.
UPnU by liquidfuse January 23, 2011
Related Words
upanup upnus upupu unupfuck upcupping updup UPnP upnush upupdowndown Upupup
The horrid noise you never want to hear in a high school.
Upupu, welcome to Hope's Peak Academy!
To be raised, be heightened, go up.
"The quality of submissions is upanup."
upanup by Chrekol July 18, 2005

upupdowndown 

Wildly popular YouTube gaming channel managed by Austin Creed {alter ego of WWE personality Xavier Woods}, the name is derived from the beginning of the Konami Code.
"Welcome to UpUpDownDown, I'm your host Austin Creed!"
upupdowndown by Mythical_beastsaber December 20, 2016

upupdowndownleftrightleftrightba 

Its the konami code ! To get 99 lives in gradius,contra,other games. Or to use in sites to use if its a secret on that site.
Example:
Bob: I KNOW THE KONAMI CODE!
Matt: What is it?
Bob: upupdowndownleftrightleftrightba
To 'big up' someone or something, it's the word UP said three times in quick succession.

To be pronounced in a South Yorkshire accent aka oop oop oop with a soft 'oo' and not like poop
"Big up to ma crew upupup!!"

"Upupup, brapbrap!"
Upupup by Wellnaughty August 12, 2012