To get a better quality product or more quantity of that product for the regular price, particularly when you are at a fast food restaurant or when requesting sexual deeds from prostitutes.
I ordered a small drink, and asked for the ghetto-upgrade, and received a large for the small price.

La-tisha gave me da full ryde fo da price of a lil somethin' somethin'. Dat shit was a ghetto-upgrade!!
by ghetto upgrade vince June 7, 2009
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A medical procedure which will—if and when it becomes reality—allow patients to modify and logically upgrade their genes to eliminate certain genetic problems, diseases, increase their intelligence, physical height; change the color of their hair, eyes, skin; increase or decrease the size of certain body part(s); and bring about other specific changes.
Marsha underwent a DNA upgrade, and in about 7-years, when her body has accepting her entire DNA upgrade she will be 5-inches taller. As of today she will be growing a tiny bit each day. It remains to be seen if all or only some children of DNA upgrade patients inherit their parent's upgraded DNA.
by but for May 20, 2018
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When something is changed and called better but is really made worse and less user-friendly; a downgrade. Usually irreversable.
Bill: Dude, have you seen the new MSN? It's total crap!

Jake: Definitely a Facebook upgrade then.
by Aniki20 January 11, 2011
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our area was so fucked up so they did a ghetto upgrade and now we have a supermarket
by pseudo nymmm April 16, 2009
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A phone call made or received, usually via wireless phone, which becomes heated and dramatic, eventually causing one of the callers to violently throw their handset and causing it irreversible damage making it necessary to replace the device with the latest available model.
I was feeling kinda lonely and decided to give my EX a call and guess who answers? My best friend. I should have known it would turn out to be an Upgrade Call. Oh well, at least my new phone plays mp3s...
by Sulm March 13, 2007
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A type of errand characterised by upgrading, usually in the context of technology.
Im gonna run an upgrade errand and get a new pc.
by Godlike Wisdom January 10, 2020
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