Top Definition
Abbreviation for "Up For".
Often used when enquiring about the possiblity of sexual relations with a member of the opposite sex.
Dude: "Hey baby, upfa?"
Chick: "No"
Dude: "Bitch!"
by Bettsy September 20, 2006
1 more definition
(Pronounced oopfa) Stands for Upper Pussy Fat Area. Or the fat that hangs over a woman's vagina.
Dude, look at Mrs. Walkers UPFA!
by DustinJ March 13, 2010

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