Top Definition
An illegal drug, specifically crack cocaine. The origin of this word is a portmanteau of the painkiller Tylenol and the name of Dave Chappelle's lovable crackhead, Tyrone Biggums. Not to be taken by anyone over a mental age of two.
"Damn, son, I feel like I got worms under my skin! Where's my dealer? I gotta refill my prescription of tyronol."

(A better idea would be to get clean.)
by Shamonan May 06, 2006

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