Top Definition
also known as a twit bffl, twit buddy, twit bestie etc.

to be best friends with someone on twitter.
or you just get lots of @replies back and forth with a particular person.
@rosiearmstrong isnt cool anough to have a twit biff. but @swayswayhayley is. so is @akashamead her twit biff is @michaellington
by swayswayhayley July 30, 2009
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