is when you had drugs, such as cocaine, or weed and you are coming down from the drug then you start
Johnny has gotten high and is lookin for sum more. Johnny is tweekin real bad.
by eazye64 January 21, 2008
to get upset and act agitated.
Student to teacher: "Mr. Smith, you be tweekin'. I didn't really do anything wrong."
by Joshua Aasgaard August 22, 2005
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