tweeker-cheeks Share definition Flag When u suck on anything(i.e. straw, pipe, cigarette, etc.) so hard your cheeks cave in, making you look like a tweeker. "damn, you got tweeker-cheeks trying to get the last drops of that drink." tweeker-cheeks by LittleLette May 6, 2009 0 0 Get merch Get the tweeker-cheeks mug. Buy Now — $32.95 See more merch