Top Definition
The forecasted outcome of one's functionality after ambitiously experimenting with methamfriendofmine. Most likely related to quality of product.


The story on where the dealer is with the dope and how long before he delivers the product. Loosely related to the tweaker's time lapse, a bad tweaknosis often causes minor cases of tweaking out.
"The tweaknosis is, this is way better than the last shit. This is that fire, real talk. It'll knock your dick in the dirt, bro."


"Yo, what's the tweaknosis?"
"Dude said he'd be here when he gets here. ?"
by D. Z. Tweakerton, Esq. February 13, 2013
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