The hours between 4 and 7am, when early birds are waking up from a good night's sleep, but drug users or "tweakers" are still up from the night before.
"Hey Jim, you're up bright and early today!"

"Nah Bob, I'm just still awake from yesterday. Been smoking crack for 12 hours, it's Tweaker Midnight for me dawg."
by flurpy May 20, 2022
Get the tweaker midnight mug.