Top Definition
A debilitating disease most commonly caused as a side affect to the drug Zortafrinex. If you can not speak or react due to the extreme pain of total scrotal implosion have a loved one call 911. there is no cure for TSI.
total scrotal implosion: its real, its here, and its killing everywhere.
by cusshinpushcushinpushin696969 February 10, 2011

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