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1.
Excuse given by those supporting the wealthy establishment for why millions in taxpayer dollars should be given to large corporations to prevent them from defaulting.
Fake News made sure to drive the point home every few minutes that $10 billion needed to be given to Goldman Sachs because it is too big to fail (that is, so that their investors wouldn't take such a hard hit).
by rich rick July 19, 2011
 
2.
A turd, that by itself, is large enough to clog the toilet without the use of paper, possibly needing to be broken up with plunger etc.
"I took a mean dump this morning. I had to poke at it with a plunger until it went down. That shit was just too big to fail"
by joshuajdickerson April 19, 2009