'Tissue-mellons' is a phenomenon generally recoursed by small breasted girls with insufficient capital to undergo a breast cosmetic surgery. Such girls, striving to boost their self-confidence, wad layers of tissue paper in the bra until a form of cleavage is somewhat contrived. More often than not, this practice ends up exacerbating the whole situation. This is beacuse when the tissue-melloned female proceeds to carnal knowledge, the man's first reactions at the bare pigeon-tits, may have considerable negative effects on the self-esteem of the former - possibly goading the girl to add more tissue-paper the next time she goes out. The 'tissue-mellons' is a vicious cycle.
Example 1
Mary: Hurry up the taxi is here! The party starts in 15 minutes!
Sue: Fuck! Why are we out of toilet paper on a Saturday night?!
Mary: Come on let's go! You can tissue-mellons your boobs later!
Sue: fucking tits!!
Example 2
John: did you bang that chick yesterday?
Peter: yeah dude. I took her to my place and guess what?! She was tissue-melloned! But I fucked her anyways.
When someone has to hand a grown man a tissue for his mommy issues because he is acting like a little bitch.
Example: Someone could say “Do you need a tissue for your missue” or missues if it is pleural or there are multiple mommy issues one is crying over.
Sarah asked David “Do you need a tissue for your missue, David?” because he is crying about his gf Beth again; Something about his dinner being cold...
when the tissue box fails to reload after someone before you has used it, forcing you to panic for 10 minutes trying to get the damn tissue out of the box using only your pointer and middle finger before someone notices your embarrassing dilemma. Usually takes place in an environment where a snot rocket isn't an option (boss' office, girlfriend's house)