A disease in which no matter what group of people you're with you're always the one left out.
"I can't believe I got ignored tonight again"

"Yeah that Third Wheel Syndrome is quite the killer"
by Mr.Mac34 January 11, 2015
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Third wheel syndrome is a problem with a person who can be in a conversation but pays no attention to it what so ever has a tendency to repeat what others have just said as they were not listening.it comes from never being someone number one person in life so they have never had attention paid to them fully thus never had to pay attention gets a lot worse over time
Mary: did you both see breaking bad last night
Sarah : yes was great
Mary: Tina ?
Tina : what?
Mary : ugh you have third wheel syndrome bad babe
by ByRik February 10, 2021
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