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4. the big A
someone with a huge ass.
"Look at the big A over there!"
"Yeah, I'd tap that."
1. the Big A
slang for the city of Anaheim, California which is located in Orange County near LA. the name is derived from the giant letter A outside of Anaheim stadium which can be seen from the 57 freeway.

A-town is a word commonly mistaken for the city of Anaheim which in reality refers to Atlanta, Georgia.
I'm representin from the Big A.
2. the big A
Anal sex. Particularly gay male anal sex. From the film Reality Bites (1994)
Sammy Gray/SteveZahn: "I think the real reason that I've been celibate for so long isn't really because I'm that terrified of the big A, it's because I can't really start my life without being honest about who I am."
3. The Big A
If you are sick and you come to work and complain about being sick, then everyone can make fun of you for having "The Big A".. i.e. AIDS.

Note: You may not actually want to use this word if you suspect someone actually has AIDS.
Dan comes to work with a cold. His eyes are watering and her nose is running. Coworkers mock him mercilessly for having "The Big A."
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