Thanksgiving mix is created when you mix 4 or more different strains of weed. It is dubbed thanksgiving mix because the only other time you have a similar culmination of good times and great taste is thanksgiving. Imagine each strain as a different side and the thanksgiving mix is each side mashed up on a plate. Thanksgiving mix is best utilized when rolled as a blunt, J, spliff ect.
Note: One J has been known to get 5 people quite high. Also "thanksgiving mix" can be long to say so it is common to just call it " the mix"
"yo man lets break out the thanksgiving mix"
"Dude i just added green crack and sour d to the mix, its bound to get gnarly from here"