When a woman takes testosterone in order to "transition" into being a transman, and encounters the severe physical, physiological and mental side effects from an artificially induced endocrine disorder. Symptoms are not unlike those for abuse of other steroids, of which testosterone is one: irritability, rage, promiscuity, lack of emotional control, violent outbursts, abnormal hair growth, male pattern baldness, damage to fertility, vocal chord damage, skeletal deformation.
A: How is she now that she's detransitioned?
b: She's okay, but it's hard to know the long-term effects of testosterone poisoning.
by TSCX October 5, 2023
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When a trans woman goes through male puberty and grows facial hair and her voice deepens, etc.
Erika, though she had boobs from taking estrogen and had had all hair facial hair lasered off, was still getting clocked because of her deep voice as a result testosterone poisoning.
by Natalia Boa Vista November 22, 2016
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When a man dies as a result of doing something that is both stupid, and something one would normally associate with steretypical "dumb guy" activity.

"The actions of the nominees are so shortsighted, so counter to common sense, that they can only be explained by the apparent need to strut superior risk-taking capacity."
- from The Darwin Awards (first book)
A Houston man earned a succinct lesson in gun safety when he played Russian roulette with a .45-caliber semiautomatic pistol. Rashaad, nineteen, was visiting friends when he announced his intention to play the deadly game. He apparantly did not realize that a semiautomatic pistol, unlike a revolver, actually inserts a cartridge into the firing chamber when the gun is cocked. His chance of winning a round of Russian Roulette was zero, as he quickly discovered.

- Darwin Awards, page 192
by Ugliness Man July 1, 2004
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The irrational rage a man goes into after being denied or not participating in sexual relations after regularly getting some.
(2 weeks with out sex)
guy: ahhhhh! she is such a bitch.
friend: what the hell are you talking about.
guy: she can't do anything right
friend: you are being unreasonable... wait, how long since you two did the bad stuff?
guy: iono two weeks
friend: oh... looks like you got testosterone poisoning dude.
by sdfjklasdfkj August 16, 2008
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When guys try to act more manly and macho than the other guys to impress each other. Often leads to idiodocy and dangerous risk taking.
All they talked about was who's truck was bigger to impress me. Tsk. Testosterone poisoning.
by Harmony1812 September 5, 2019
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