A word very valuable in situations where you are playing Scrabble and wish to temporarily infuriate your opponent with your apprent complete disregard for the simple dictionary-based rules of the game, only to have them remark in your favour with a certain astonishment when they discover it really is a word.
"syzygy?! That's not a word!!"
"It is so! Go ahead look it up!"
"Alright..." (time passes as opponent flicks through the dictionary) "... God damnit..."
The near perfect linear alignment of 3 or more celestial bodies (as in the sun the moon and the earth during a solar eclipse) in a gravatational system.
A total-harmony state achieved by a group of meditation-minded "in tune with the power of the Universe" hippies while engaged in perfectly-in-sync cutting/trimming of paper/fabric with "syzzors".
Performing syzzygy with your weed-puffing buddies can indeed be relaxing, but your hands get tired fairly soon from all of that synchronized snippin'.
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.