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2.
1. A form of greeting
2. Bragging, trash talking. Like saying sup after you gain some advantage over the other person.
Person1: Sup wit it G?
Person2: Not much just ballin'

Person 3: SUP WIT IT
Person 4: Haha fuck that was a sick beatdown you gave that fake thug, man I wish I had been able to do that shit.

by MAKAVELI604 June 16, 2007
 
1.
Used to say "What's up?" created by Three B in 2006. Response is "Super Sick Wit It"
"Sup Wit it?"....."Super Sick wit it!"
by Issa and bh cole April 13, 2006
 
3.
a sad attempt at asking 'whats up' in a text message
supwitit.
ez-b
by lauxessss January 18, 2009