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1.
A person who initially pisses u off because of their very presence and then pisses u off even more for their stupidity.
Annoying fuck: I fucked ur girlfriend last night.

Dude : U r one stupid son of a bitch...fuck you
by anon5555 October 12, 2009
 
2.
The most completely encompassing insult one can possibly convey to another human being. First, a general insult is made, but then it becomes personal.
God damnit Bill, you're a stupid son of a bitch.
by JonReremy March 06, 2009