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1.
Shut up. Said in a grumpy way, but usually to a friend and not meant to be too rude.
Roommate one: I'm done with all my gen eds!
Roommate two: Stuff it.
by katomicbomb February 15, 2008
 
2.
To give up on something; To not care or be bothered about/with something/someone. Another way of saying "screw this".
"Stuff it I can't be bothered to do this work any more"
by Little Hands April 15, 2009
 
3.
A suggestion by one person to another recommending they stick it in their ass and shut-up.
Stuffit holmes, bitch don't need to hear that shit, show respek.
by Jim Inman August 16, 2006