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It's when your being cocky in a fight and someone hits you say:
Well, that stuck a nerve.

to show that, "oh look, i could hardly tell but i think this chap wants to fight me...."
by jason March 01, 2005

Words related to strike a nerve

boob bring down knock down ko smackdown strike down
to distress somebody through commentary
Did I strike a nerve when I called him a boob?
by thunderdog August 23, 2006