To get ready by consuming a drug
"Lets spike up before we go to the concert"
by 420666 September 29, 2007
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the action of both preparing yourself to overcome adversity and following through. This phrase is often used as a an exclamatory.
I just went to the gym for 6 hours and got an A on my final exam. Time to go party, spike up baby!

OR Man i'm high as shit but its time to spike up and leave it all on the court. Spike Up!
by Johnathan And The October 19, 2020
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To challenge another track team member to a race to prove who is faster.
James: All you freshman are soo slow.
Q: James, why you talk all this trash, you know i can smoke you in a race.
James: Alright then , Spike Up Baby and lets go.
by Ek, the Decath November 27, 2009
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